Related Experiment Video
Updated: May 3, 2026

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
Published on: January 24, 2013
[Circadian rhythm and mood disorder]
1Department of Psychiatry, Nihon University School of Medicine.
Abstract:
Mood disorders show a common feature of distorted cycling of biological systems, manifesting, for example, as diurnal mood variation in depression, phasic time course in bipolar disorder, and seasonal mood swing in seasonal affective disorder. Accordingly, circadian dysfunction has been supposed to play an etiological role in mood disorders. Increasing evidence indicates that circadian misalignment between neuroendocrinological rhythm and the timing of sleep correlates with the severity of symptoms. In addition, several genetic studies have suggested that certain clock gene variants play a role in vulnerability to these disorders, and especially bipolar disorders. However, the role of circadian phenotypes and circadian genes in mood spectrum disorders remains unclear, although currently seem to have a pathoplastic rather than a pathogenetic effect.
More Related Videos
Related Concept Videos
Circadian Rhythms and Gene Regulation
Circadian Rhythms and Gene Regulation
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
Bipolar Disorder
Management of Insomnia
Biological Clocks and Seasonal Responses

