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Differences in clinical features between children and adults with dengue hemorrhagic fever/dengue shock syndrome

Vannyda Namvongsa1, Chukiat Sirivichayakul2, Sirilak Songsithichok3

  • 1Department of Medicine, University of Health Sciences, Ministry of Health, Lao PDR.

The Southeast Asian Journal of Tropical Medicine and Public Health
|January 21, 2014
PubMed

Insights

Children with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) showed more severe plasma leakage and symptoms like anorexia and rash compared to adults. Adults, however, required more blood transfusions, highlighting age-related differences in DHF/DSS presentation.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Pediatrics

Background:

  • Dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) is a significant public health concern.
  • Clinical manifestations of DHF/DSS can vary between age groups.
  • Understanding these differences is crucial for effective patient management.

Purpose of the Study:

  • To compare the clinical features of DHF/DSS in children versus adults.
  • To identify age-specific patterns in DHF/DSS presentation and severity.
  • To provide insights for clinicians managing pediatric and adult DHF/DSS patients.

Main Methods:

  • Retrospective study design.
  • Inclusion of 273 DHF/DSS patients admitted to Ratchaburi Hospital, Thailand (January 2007 - May 2008).
  • Analysis of clinical signs, symptoms, laboratory findings, and outcomes stratified by age (children vs. adults).

Main Results:

  • Common symptoms included nausea/vomiting, positive tourniquet test, anorexia, hemoconcentration, headache, abdominal tenderness, myalgia, and pleural effusion.
  • Children exhibited higher rates of anorexia, positive tourniquet test, abdominal tenderness, and convalescent rash.
  • Children showed more pronounced plasma leakage (lower serum albumin/sodium, higher pleural effusion, ascites, shock); adults required more blood transfusions.

Conclusions:

  • Significant differences exist in DHF/DSS clinical features between children and adults.
  • Children present with more severe plasma leakage and specific symptoms.
  • Adult DHF/DSS patients may have a higher need for blood transfusions, warranting tailored clinical approaches.

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