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Macrolide resistant Streptococcus pneumoniae in Charoenkrung Pracharak Hospital, Thailand

Kajorn Inthraburan1

  • 1Department of Medicine, Charoenkrung Pracharak Hospital, Service Department, Bangkok Metropolitan Administration, Thailand. jorn2001@hotmail.com

The Southeast Asian Journal of Tropical Medicine and Public Health
|January 21, 2014
PubMed

Insights

Macrolide resistant Streptococcus pneumoniae is rising in Southeast Asia. Resistance to erythromycin in S. pneumoniae increased significantly at Charoenkrung Pracharak Hospital from 2000-2011.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Macrolide resistant Streptococcus pneumoniae (S. pneumoniae) is a growing public health concern, particularly in Southeast Asia.
  • Erythromycin resistance in S. pneumoniae has been observed to be increasing.
  • Previous studies have indicated a correlation between macrolide and penicillin resistance.

Purpose of the Study:

  • To evaluate the trends and prevalence of macrolide resistance in S. pneumoniae.
  • To determine the correlation between macrolide resistance and penicillin resistance in S. pneumoniae.
  • To assess the implications for clinical treatment and prophylaxis.

Main Methods:

  • A retrospective review of S. pneumoniae isolates was conducted from patient data between 2000 and 2011.
  • Drug resistance patterns, specifically to erythromycin, were analyzed.
  • Statistical analysis was performed to identify correlations between macrolide and penicillin resistance.

Main Results:

  • Of 390 patients, 158 (40.5%) had S. pneumoniae isolates resistant to macrolides.
  • A significant increase in macrolide resistant S. pneumoniae was observed over the study period.
  • A strong positive correlation was found between macrolide resistance and penicillin resistance (p<0.001).

Conclusions:

  • Macrolide resistance in S. pneumoniae has significantly increased at Charoenkrung Pracharak Hospital.
  • The co-resistance with penicillin highlights the complexity of antibiotic resistance.
  • Macrolide monotherapy should be used with caution for suspected S. pneumoniae infections.

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