Quantification of mitral regurgitation by general imaging three-dimensional quantification: feasibility and accuracy

Area of Science:

• Cardiovascular Imaging
• Echocardiography
• 3D Quantification

Background:

• Mitral regurgitant volume (MRvol) is crucial for assessing mitral regurgitation (MR) severity, but its measurement is challenging.
• General Imaging 3D Quantification (GI 3DQ) enables direct MR jet volume measurement, leveraging advanced probe and software technology.

Purpose of the Study:

• To evaluate the feasibility and accuracy of MRvol quantification using GI 3DQ.

Main Methods:

• Ninety-three patients with MR (61 functional, 32 prolapse; 41 central, 52 eccentric) were studied.
• MRvol was measured using GI 3DQ and the proximal isovelocity surface area (PISA) method.
• Reference method: MRvol derived from effective regurgitant orifice area and MR time-velocity integral via real-time 3D echocardiography.

Main Results:

• GI 3DQ and PISA methods showed good correlation with the reference MRvol.
• Both methods significantly underestimated MRvol in eccentric MR.
• No significant underestimation was found for central MR.

Conclusions:

• MRvol quantification with GI 3DQ is feasible.
• GI 3DQ provides accurate central MRvol assessment compared to the reference method.
• GI 3DQ MRvol quantification demonstrates no significant difference from the PISA method.