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Pulmonary alveolar proteinosis in adenosine deaminase-deficient mice

Rupreet Dhanju1, Weixian Min2, Cameron Ackerley3

  • 1Developmental & Stem Cell Biology Program, Hospital for Sick Children, Toronto, Ontario, Canada; Faculty of Medicine, Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

The Journal of Allergy and Clinical Immunology
|January 21, 2014
PubMed
Abstract

No abstract available in PubMed .

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Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
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