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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: May 3, 2026

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
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Tumor antigenicity revealed.

Peter A Savage1

  • 1Department of Pathology, University of Chicago, Chicago, IL 60605, USA.

Trends in Immunology
|January 21, 2014
PubMed
Summary
This summary is machine-generated.

Somatic mutations in cancer patients create mutated peptide antigens that may trigger an immune response. Recent studies using exome sequencing help identify these potential tumor antigens.

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Area of Science:

  • Oncology
  • Immunology
  • Genomics

Background:

  • Tumor antigenicity is crucial for anti-cancer immune responses.
  • The role of neoantigens derived from somatic mutations in human cancer immunity remains incompletely understood.

Purpose of the Study:

  • To investigate the contribution of mutated peptide antigens to tumor antigenicity in human cancer.
  • To analyze recent findings from studies employing tumor exome sequencing for neoantigen prediction.

Main Methods:

  • Exome sequencing of tumor samples.
  • Bioinformatic prediction of candidate mutated neoantigens.

Main Results:

  • Two recent studies utilized tumor exome sequencing to predict potential mutated antigens.
  • These studies offer new insights into the significance of neoantigens in cancer.

Conclusions:

  • Mutated peptide antigens arising from somatic mutations are important contributors to tumor antigenicity.
  • Exome sequencing is a valuable tool for identifying neoantigens and understanding cancer immunity.