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Related Concept Videos

Testes: Gross Anatomy01:19

Testes: Gross Anatomy

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The testes, also known as testicles, are the male gonads. They are housed within the scrotum, a sac-like structure located beneath the penis. The scrotum's primary role is to regulate the temperature of the testes, which is crucial for sperm production.
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
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Testes: Histology01:27

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A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Menopause01:28

Menopause

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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Disorders of the Male Reproductive System01:20

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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
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Spermatogenesis01:41

Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Germ Cell Transplantation and Testis Tissue Xenografting in Mice
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[Aging of the human testis].

Louis Sibert1, Emeric Lacarrière2, Athmane Safsaf1

  • 1CHU-Hôpitaux de Rouen, hôpital Charles-Nicolle, service d'urologie, 76000 Rouen, France; CHU-Hôpitaux de Rouen, EA 4308 « Gamètogenèse et qualité du gamète », IRIB, université de Rouen, 76000 Rouen, France.

Presse Medicale (Paris, France : 1983)
|January 21, 2014
PubMed
Summary

Testicular aging causes physical changes and reduced sperm quality in men. While fertility may not be significantly impacted, androgen decline and age-related diseases are key clinical concerns.

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Area of Science:

  • Reproductive biology
  • Andrology
  • Gerontology

Context:

  • Testicular aging involves progressive morphological and histological changes.
  • Male reproductive function declines with age, affecting sperm parameters and hormone production.

Purpose:

  • To detail the morphological and histological changes in the aging testis.
  • To analyze the impact of aging on male reproductive parameters and fertility.

Summary:

  • Testicular aging is characterized by decreased volume, arteriolar sclerosis, Leydig and Sertoli cell degeneration, germ cell depletion, and tunica albuginea thickening.
  • Aging male sperm quality declines, with reductions in volume, concentration, motility, and morphology. Leydig cell reduction contributes to androgen decline.
  • Despite reduced sperm quality, fertility in elderly men may not be significantly compromised, though clinical impacts include decreased androgens and age-associated diseases.

Impact:

  • Provides a comprehensive overview of testicular aging's effects on male reproductive health.
  • Highlights the importance of considering interindividual variability and methodological differences in research on male aging.
  • Informs clinical understanding of age-related reproductive changes and associated health risks in men.