Rhinosinusitis
Related Experiment Video
Updated: May 3, 2026

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
Published on: September 22, 2023
Alexi DeCastro1, Lisa Mims2, William J Hueston3
1Department of Family Medicine, Medical University of South Carolina, 5 Charleston Center, Suite 263, MSC 192, Charleston, SC 29415-0192, USA; Department of Family Medicine, MUSC Family Medicine Center, 560 Ellis Oaks Drive, Charleston, SC 29425-0192, USA.
Abstract:
Although sinusitis is common, controversy exists regarding terminology, diagnostic criteria, indications for imaging, and treatment guidelines. Patients who are diagnosed with bacterial sinusitis should be started on amoxicillin-clavulanate unless an allergy to penicillin is reported, in which case doxycycline or a respiratory fluoroquinolone is indicated for non-pregnant patients. Patients who fail to respond to antibiotic therapy should be suspected of having chronic sinusitis, which may requirea dditional therapy, including endoscopic surgery. Referral of these patients to an otolaryngologist for further evaluation is recommended. Patients with severe systemic symptoms including altered mental status or severe headaches should be suspected of having fungal sinusitis and to an otolaryngologist acutely because this condition has high mortality if not treated emergently.
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