Related Experiment Video
Updated: May 3, 2026

Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
Published on: January 26, 2018
[Pharmacology of misoprostol (pharmacokinetic data, adverse effects and teratogenic effects)]
J Aubert1, T Bejan-Angoulvant1, A-P Jonville-Bera1
1Service de pharmacologie clinique, centre régional de pharmacovigilance, CHRU de Tours, 2, boulevard Tonnellé, 37044 Tours cedex, France.
Abstract:
Misoprostol is a synthetic analogue of prostaglandin E1. It is used in gynaecology because of its properties of myometrium smooth muscle cells contraction and its effects on the cervix. Misoprostol oral bioavailability is low and several authors have assessed whether the administration by other routes increased its pharmacodynamic effects. This paper summarizes the pharmacokinetic studies after other routes of administration: vaginal, sublingual, buccal or rectal. It also provides an update on its adverse effects and teratogenic effects.
More Related Videos
09:04Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
Published on: September 10, 2018
09:59Biaxial Basal Tone and Passive Testing of the Murine Reproductive System Using a Pressure Myograph
Published on: August 13, 2019
Related Concept Videos
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Teratogenicity
Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
Pharmacokinetics: Drug–Drug Interactions
Pharmacogenetics of Drug Metabolism: Overview