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Reduced coffee consumption among individuals with primary sclerosing cholangitis but not primary biliary cirrhosis

Craig Lammert1, Brian D Juran1, Erik Schlicht1

  • 1Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|January 21, 2014
PubMed

Insights

Coffee consumption is lower in patients with primary sclerosing cholangitis (PSC), but not primary biliary cirrhosis (PBC), compared to healthy individuals. This study explored coffee habits in autoimmune liver diseases.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Autoimmune Diseases

Background:

  • Coffee consumption is linked to reduced liver disease risk.
  • Limited research exists on coffee's role in cholestatic autoimmune liver diseases like PBC and PSC.

Purpose of the Study:

  • To investigate the association between coffee consumption and the risk of primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC).

Main Methods:

  • A large North American cohort study involving 606 PBC patients, 480 PSC patients, and 564 healthy controls.
  • Lifetime coffee drinking habits were assessed via questionnaires.
  • Logistic regression analysis adjusted for age, sex, smoking, and education.

Main Results:

  • Patients with PSC reported lower coffee consumption than controls, with a higher percentage of never-drinkers and fewer current drinkers.
  • PSC patients consumed fewer cups per month and a smaller lifetime percentage of coffee consumption compared to controls.
  • Coffee consumption did not differ between PBC patients and controls.

Conclusions:

  • Coffee consumption is significantly lower among individuals with PSC, but not PBC, compared to healthy controls.
  • Findings suggest a potential difference in coffee's relationship with PSC versus PBC.
Abstract

Keywords:
Biliary InflammationCaffeineCholestasisRisk FactorUC

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