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Related Concept Videos

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Related Experiment Video

Updated: May 3, 2026

Homochronic Transplantation of Interneuron Precursors into Early Postnatal Mouse Brains
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Genetic programs controlling cortical interneuron fate.

Nicoletta Kessaris1, Lorenza Magno1, Anna Noren Rubin1

  • 1Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.

Current Opinion in Neurobiology
|January 21, 2014
PubMed
Summary

Cortical interneuron development in rodents originates in the embryonic subcortical telencephalon. Research identifies transcription factors and external factors influencing interneuron subtype specification and fate.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Cortical interneurons originate from the embryonic subcortical telencephalon.
  • Distinct neuroepithelial precursors generate specific interneuron subsets.

Purpose of the Study:

  • Identify molecular determinants of interneuron subtype identity.
  • Understand pathways for acquiring mature interneuron traits.

Main Methods:

  • Investigate transcription factors involved in interneuron development.
  • Explore extrinsic influences on cell fate specification.

Main Results:

  • Several transcription factors identified as key regulators.
  • Emerging understanding of pathways for interneuron maturation.

Conclusions:

  • Interneuron development is shaped by both genetic and extrinsic factors.
  • Further research needed on the interplay between genetic programs and external influences for cell fate specification.