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Related Experiment Video

Updated: May 3, 2026

Determining Genetic Expression Profiles in C. elegans Using Microarray and Real-time PCR
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Published on: July 30, 2011

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Extensive oscillatory gene expression during C. elegans larval development.

Gert-Jan Hendriks1, Dimos Gaidatzis2, Florian Aeschimann1

  • 1Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland; University of Basel, Petersplatz 1, CH-4003 Basel, Switzerland.

Molecular Cell
|January 21, 2014
PubMed
Summary
This summary is machine-generated.

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Gene expression in developing C. elegans worms shows widespread, synchronized, large oscillations. These rhythmic patterns, driven by periodic transcription, suggest new insights into coordinated gene expression and animal development.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genomics

Background:

  • Oscillations are fundamental to dynamic biological processes, observed in systems from the heart to embryonic development.
  • Understanding the role and mechanisms of gene expression oscillations is crucial for deciphering developmental timing and function.

Purpose of the Study:

  • To investigate pervasive gene expression oscillations in developing C. elegans larvae.
  • To characterize the amplitude, periodicity, and regulatory mechanisms of these oscillations.
  • To explore the functional implications of rhythmic gene expression in animal development.

Main Methods:

  • Utilized ribosome profiling and RNA sequencing to analyze gene expression patterns in developing C. elegans.
  • Quantified transcript oscillations across different developmental stages.

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  • Assessed the synchronization of gene expression across tissues.

    • Main Results:

    • Discovered pervasive, large-amplitude, phase-locked gene expression oscillations with an 8-hour period in nearly one-fifth of transcripts.
    • Observed significant fold-changes (>10-fold) in hundreds of oscillating transcripts.
    • Demonstrated that periodic mRNA accumulation leads to rhythmic translation, impacting protein levels and complex structure formation (e.g., cuticle).
    • Confirmed robust synchronization of gene expression programs across cells and tissues.

    Conclusions:

    • Gene expression oscillations are a widespread phenomenon in C. elegans development, extending beyond molting-related functions.
    • Rhythmic translation driven by mRNA oscillations plays a key role in protein dynamics and cellular organization.
    • These findings establish C. elegans as a powerful model for studying synchronized gene expression and its role in animal development.