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Effect of long-term storage on monoamine metabolite levels in human cerebrospinal fluid
K Kobayashi1, Y Imazu, M Kawabata
1Department of Clinical Neurochemistry, Okayama University Medical School, Japan.
Acta Medica Okayama
|August 1, 1987
Abstract:
Concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) were measured in human cerebrospinal fluid (CSF) following long-term storage at -20 degrees C for intervals of three to 60 months. No significant changes in HVA levels were detected in CSF stored for up to 60 months. On the other hand, 5-HIAA concentrations remained stable for up to 6 months, but decreased significantly in the specimens stored for longer time intervals. The results indicate that 5-HIAA should be determined within 6 months after CSF collection, while HVA determinations may be delayed.