Related Experiment Video

Updated: May 3, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

10.3K

Association of aging, arterial stiffness, and cardiovascular disease: a review

Murugapathy Veerasamy1, Gary A Ford, Dermot Neely

  • 1From the *Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, United Kingdom; †Institute of Ageing and Health, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, United Kingdom; ‡Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, United Kingdom; §Department of Biochemistry, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, United Kingdom.

Cardiology in Review
|January 21, 2014
PubMed

Insights

Arterial stiffness is a key independent risk factor for coronary heart disease (CHD), even with conventional treatments. Understanding this link is crucial for improving cardiovascular disease prevention strategies.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Public Health

Background:

  • Coronary heart disease (CHD) remains a leading cause of death globally.
  • Despite advances in prevention and pharmacotherapy for conventional risk factors, CHD incidence is increasing in developed nations.
  • Arterial stiffness is recognized as an independent predictor of cardiovascular events.

Purpose of the Study:

  • To review the association between arterial stiffness and cardiovascular disease.
  • To highlight the significance of arterial stiffness beyond traditional risk factors.
  • To inform future prevention strategies for coronary heart disease.

Main Methods:

  • Literature review of studies investigating arterial stiffness and cardiovascular disease.
  • Analysis of epidemiological data and clinical trial outcomes.
  • Synthesis of evidence linking arterial stiffness to CHD development and progression.

Main Results:

  • Arterial stiffness independently predicts cardiovascular events in both general and high-risk populations.
  • Increased arterial stiffness is associated with a higher incidence of coronary heart disease.
  • This association persists even after accounting for established cardiovascular risk factors.

Conclusions:

  • Arterial stiffness is a critical, independent risk factor for coronary heart disease.
  • Assessment and management of arterial stiffness may offer novel avenues for cardiovascular disease prevention.
  • Further research into interventions targeting arterial stiffness is warranted.

More Related Videos

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

17.1K
Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

17.8K

Related Concept Videos

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
948
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.5K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.6K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
890
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
611