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Individualizing fortification of human milk using real time human milk analysis
P G Radmacher1, S L Lewis2, D H Adamkin1
1Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA.
Journal of Neonatal-Perinatal Medicine
|January 21, 2014
Summary
Real-time analysis of human milk (HM) helps calculate final composition after fortification. Individualized fortification based on actual milk profiles ensures better nutrient targets for preterm infants.
Area of Science:
- Nutritional Science
- Biochemistry
- Neonatal Nutrition
Background:
- Human milk (HM) fortification is crucial for preterm infants.
- Standard fortification protocols may not meet individual infant needs.
- Accurate macronutrient analysis of HM is essential.
Purpose of the Study:
- To assess the final composition of fortified human milk using real-time macronutrient analysis.
- To compare standard versus individualized fortification protocols.
- To guide fortification practices for preterm infants.
Main Methods:
- Mid-infrared spectroscopy analyzed protein, fat, and lactose in preterm HM (PHM) and donor DHM.
- Energy content was calculated from macronutrient data.
- Four milk profiles demonstrated individualized fortification outcomes.
Main Results:
- Lactose levels were similar in PHM and DHM.
- DHM had significantly lower protein and fat compared to PHM.
- Standard fortification failed to meet protein and energy targets in some cases.
- Individualized fortification improved accuracy in meeting nutrient recommendations.
Conclusions:
- Real-time HM analysis provides accurate macronutrient assessment for guiding fortification.
- Individualized fortification protocols are recommended to achieve optimal nutrient content.
- This approach helps avoid unexpected nutrient deficiencies or excesses in fortified HM.
