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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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In statistical epidemiology and health sciences, two essential metrics—prevalence and incidence—are fundamental for understanding disease dynamics within a population. These measures enable public health officials, epidemiologists, and researchers to assess the burden of diseases, allocate resources effectively, and design impactful public health policies and interventions.
Prevalence indicates the proportion of individuals in a population who have a specific disease or health...
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Encephalitis l: Introduction01:19

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Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...
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Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

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Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
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Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

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Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
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Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

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The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
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Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
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Multiple sclerosis: Etiology, incidence and prevalence.

P D Rumrill1, J C Battersby1, D A Kaleta1

  • 1University of Wisconsin - Milwaukee, Department of Educational Psychology, 733 Enderis Hall, P.O. Box 413, Milwaukee, WI, USA 53201.

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This article reviews multiple sclerosis (MS), a common neurological disease. It covers MS symptoms, diagnosis, progression, and current treatments for better patient understanding.

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Area of Science:

  • Neurology
  • Neuroscience

Background:

  • Multiple sclerosis (MS) is a prevalent neurological disorder in the Western hemisphere.
  • Understanding the multifaceted nature of MS is crucial for effective patient management.

Purpose of the Study:

  • To provide a comprehensive overview of multiple sclerosis (MS).
  • To consolidate current knowledge on MS symptomology, diagnosis, disease course, progression, and treatment options.

Main Methods:

  • Literature review of current medical, psychological, and social aspects of MS.
  • Synthesis of information on the clinical presentation and management of MS.

Main Results:

  • Detailed examination of the diverse symptomology associated with MS.
  • Information on diagnostic criteria and the typical course and progression of MS.
  • Overview of contemporary treatment strategies for managing MS.

Conclusions:

  • Multiple sclerosis (MS) presents complex medical, psychological, and social challenges.
  • Current information on symptomology, diagnosis, progression, and treatment is essential for healthcare providers and patients.