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Defining "The Elderly" Undergoing Major Gastrointestinal Resections: Receiver Operating Characteristic Analysis of a

Mark Meerdink1, Barbara L van Leeuwen, Robert A Pol

  • 1Department of surgery, University Medical Center Groningen, Groningen University, m.meerdink@umcg.nl.

Annals of Surgery
|January 21, 2014
PubMed
Abstract

No abstract available in PubMed .

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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