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Updated: May 3, 2026

Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay
Published on: May 12, 2020
[Oxidative stress in bipolar affective disorder]
E Z Reininghaus1, S Zelzer, B Reininghaus
1Universitätsklinik für Psychiatrie, Medizinische Universität Graz, Auenbruggerplatz 31, 803, Graz, Österreich, Eva.schmidt@medunigraz.at.
Abstract:
The results of mortality studies have indicated that medical conditions, such as cardiovascular disease, obesity and diabetes are the most important causes of mortality among patients with bipolar disorder. The reasons for the increased incidence and mortality are not fully understood. Oxidative stress and an inadequate antioxidative system might be one missing link and could also help to further elucidate the pathophysiological basis of bipolar disorder. This article provides a comprehensive review of oxidative stress in general and about the existing data for bipolar disorder. In addition information is given about possible therapeutic strategies to reduce oxidative stress and the use in bipolar disorder.
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