Related Experiment Video
Updated: May 3, 2026
06:19
Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay
Published on: May 12, 2020
32.6K
[Oxidative stress in bipolar affective disorder]
E Z Reininghaus1, S Zelzer, B Reininghaus
1Universitätsklinik für Psychiatrie, Medizinische Universität Graz, Auenbruggerplatz 31, 803, Graz, Österreich, Eva.schmidt@medunigraz.at.
Der Nervenarzt
|January 21, 2014
Summary
Patients with bipolar disorder have higher mortality due to cardiovascular disease, obesity, and diabetes. Oxidative stress may be a key factor, and reducing it could offer new therapeutic strategies.
Area of Science:
- Neuroscience
- Biochemistry
- Psychiatry
Context:
- Bipolar disorder is associated with significant mortality from comorbid medical conditions like cardiovascular disease, obesity, and diabetes.
- The underlying mechanisms for this increased mortality remain incompletely understood.
- Oxidative stress and impaired antioxidant defenses are hypothesized to play a role.
Purpose:
- To comprehensively review the role of oxidative stress in bipolar disorder.
- To explore the link between oxidative stress and increased mortality in bipolar disorder patients.
- To discuss potential therapeutic strategies targeting oxidative stress.
Summary:
- Mortality studies highlight cardiovascular disease, obesity, and diabetes as leading causes of death in bipolar disorder.
- Oxidative stress is proposed as a potential missing link in understanding the pathophysiology and increased mortality.
- The review covers general oxidative stress, its specific relevance to bipolar disorder, and therapeutic interventions.
Impact:
- Provides a comprehensive overview of oxidative stress in bipolar disorder.
- Identifies oxidative stress as a potential target for novel therapeutic interventions.
- Aims to improve understanding and management of medical comorbidities in bipolar disorder.
More Related Videos
09:31Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
Published on: September 17, 2021
4.0K
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
22.3K
Related Concept Videos
01:30Bipolar Disorder
1.4K
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.4K
01:24Mania and Antimanic Drugs: Overview
800
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
800
01:27Depressive Disorders: Etiology
884
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
884
01:20Psychological Responses to Stress
978
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
978
01:30Stress and Mental Health
1.7K
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...
1.7K
01:27Introduction to Stress and Lifestyle
865
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
865