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Updated: May 1, 2026

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Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones
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Hepatocellular carcinoma with colonic metastasis
Singapore Medical Journal
|January 21, 2014
Summary
Hepatocellular carcinoma rarely spreads to the colon. This case highlights a unique instance of rectal metastasis presenting with tenesmus, suggesting broader diagnostic considerations for colon involvement.
Area of Science:
- Hepatology
- Gastroenterology
- Oncology
Background:
- Hepatocellular carcinoma (HCC) is a primary liver cancer.
- Colonic metastasis from HCC is uncommon, typically occurring via direct invasion.
- Commonly reported symptoms include bloody stools.
Observation:
- This report details a rare case of hepatocellular carcinoma with metastasis to the rectum.
- The patient presented with tenesmus, a symptom not typically associated with direct colonic invasion.
- This presentation suggests a distinct route of metastasis, possibly hematogenous.
Findings:
- Hematogenous metastasis of HCC to the rectum is a previously unreported association.
- Tenesmus can be a presenting symptom of rectal metastasis from HCC.
- Bloody stools can also indicate colonic metastasis from HCC.
Implications:
- Clinicians should consider colonic metastasis in HCC patients presenting with tenesmus.
- Diagnostic evaluation for HCC metastasis should include the entire colon, not just direct invasion sites.
- This finding expands the understanding of HCC metastatic patterns.

