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Updated: May 3, 2026

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Technological advances in the hemostasis laboratory.

Giuseppe Lippi1, Mario Plebani2, Emmanuel J Favaloro3

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Automation is increasingly used in hemostasis testing, overcoming challenges like unique sample matrices. Innovations enhance reliability and efficiency, but specialized expertise remains crucial for interpreting results.

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Area of Science:

  • Clinical Diagnostics
  • Laboratory Automation
  • Hemostasis and Thrombosis

Background:

  • Automation is widely adopted in clinical chemistry and immunochemistry for diagnostic testing.
  • Extending automation to hemostasis testing presents unique challenges due to specific biological matrices and sample pretreatment requirements.

Purpose of the Study:

  • To review the advancements and challenges in automating hemostasis testing.
  • To highlight innovations improving the reliability and efficiency of hemostasis diagnostics.

Main Methods:

  • Integration of routine hemostasis analyzers with track line systems and workcells.
  • Development of specialized instrumentation for enhanced reliability, including signal detection, plasma indices, and failure pattern sensors.
  • Implementation of advanced preanalytical and postphlebotomy tools for sample handling and transport.

Main Results:

  • Significant progress in automating hemostasis testing through integrated systems and advanced instrumentation.
  • Improvements in preanalytical sample handling, operator safety, and specimen transport stability.
  • Automation enhances efficiency and reliability but does not eliminate the need for expert interpretation.

Conclusions:

  • Automation is progressively being adopted in hemostasis testing, addressing previous limitations.
  • Innovations in instrumentation and workflow management are key to successful automation.
  • Designing automation for hemostasis requires careful consideration of its unique analytical and interpretative demands.