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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
Published on: June 28, 2024
Impact of maternal diet on neonatal anthropometry: a randomized controlled trial
J M Donnelly1, J M Walsh, J Byrne
1UCD, Department of Obstetrics and Gynaecology, School of Medicine and Medical Science, Dublin, Ireland.
Insights
A maternal low glycaemic index (GI) diet in pregnancy may positively impact infant adiposity. This dietary approach was found to reduce neonatal thigh circumference, suggesting it is safe and beneficial.
Area of Science:
- Obstetrics and Gynecology
- Neonatal Health
- Nutritional Science
Background:
- Large for gestational age infants face increased risks of childhood obesity.
- Maternal nutrition significantly influences birthweight and neonatal development.
- Understanding the impact of specific maternal diets on neonatal anthropometry is crucial for long-term infant health.
Purpose of the Study:
- To evaluate the effect of a maternal low glycaemic index (GI) diet on neonatal anthropometric measurements.
- To determine if a low GI diet during pregnancy influences infant body composition.
- To assess the safety and potential benefits of a low GI diet in pregnancy.
Main Methods:
- A randomized controlled trial (ROLO study) involving 265 neonates.
- Participants were assigned to either a low GI diet or a usual diet group from early pregnancy.
- Neonatal anthropometry, including circumferences and skin-fold measurements, was assessed on days 1-2 of life.
Main Results:
- Neonates born to mothers on a low GI diet exhibited a significantly lower thigh circumference (P=0.04).
- No significant differences were observed in head, chest, abdominal, or mid-upper arm circumferences between groups.
- Maternal low GI diet did not affect any measured skin-fold thicknesses in neonates.
Conclusions:
- Maternal low glycaemic index diet during pregnancy alters neonatal thigh circumference.
- These findings indicate that a low GI diet is safe for use in pregnancy.
- This dietary intervention shows potential for positively impacting infant adiposity.
Objective:
Large for gestational age infants are at increased risk of childhood obesity and maternal nutrition impacts birthweight. The aim of this study was to assess the impact of a maternal low glycaemic index (GI) diet on neonatal anthropometry.
Methods:
The ROLO (Randomised Control Trial of Low Glycaemic Index Diet in Pregnancy) study was a randomized controlled trial to assess the impact of a low GI diet versus usual diet on birthweight. It took place in a tertiary maternity hospital in Ireland and women were randomized to receive either a low GI diet or no dietary intervention from early pregnancy to term. Two hundred sixty-five neonates had anthropometric measurements on day 1-2 of life, 126 in the intervention group and 139 in the control group. Measurements included birthweight, length and circumferences of the head, chest, abdominal, thigh and mid-upper arm. A subgroup of 219 (82%) neonates also had skin-fold measurements.
Results:
Neonates whose mothers had a low GI diet in pregnancy had lower thigh circumference (15.9 ± 1.7 cm vs. 16.6 ± 1.5 cm, P = 0.04). There was no difference between the intervention and control groups in head, chest abdominal or mid-upper arm circumferences. No difference was noted between the two groups for any skin-fold measurements (subscapular, thigh, biceps and triceps).
Conclusion:
Neonatal thigh circumference was altered by maternal low GI diet in pregnancy. These findings suggest that maternal low GI diet is safe in pregnancy and may positively impact infant adiposity.
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