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Homology among beta-crystallins: monoclonal antibodies to beta-heavy crystallin
E H Belisle1, S W Su, B W Lubit
1Department of Biochemistry, UMDNJ-New Jersey Medical School, Newark 07103.
Current Eye Research
|August 1, 1987
Abstract:
The mouse monoclonal antibodies, prepared with rat beta H-crystallin as parent antigen, show cross-reactivity to specific subunits in beta H-, beta L1-, and beta L2-crystallin but no reactivity to either alpha- or gamma-crystallins. Antigenic homology among the beta-crystallin subunits was demonstrated by comparison of the topographic distributions of peptides on two-dimensional electrophoretograms subjected to either staining or an ELISA of the immunoblots.