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Predicting medication persistence to buprenorphine transdermal system.

Joseph V Pergolizzi1, Rami Ben-Joseph, Chun-Lan Chang

  • 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, U.S.A.; Temple University School of Medicine, Philadelphia, Pennsylvania, U.S.A.; Naples Anesthesia and Pain Associates, Naples, Florida, U.S.A.

Pain Practice : the Official Journal of World Institute of Pain
|January 22, 2014
PubMed
Summary
This summary is machine-generated.

Prior use of opioids and adjuvant analgesics, along with dose adjustments, significantly increase buprenorphine transdermal system (BTDS) persistence. This suggests personalized treatment strategies improve patient adherence to chronic pain therapy.

Keywords:
opioidopioid experienceopioid naïvepersistencetransdermal buprenorphine

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Area of Science:

  • Pain Management
  • Pharmacology
  • Health Outcomes Research

Background:

  • Patient persistence on therapy is crucial for managing chronic conditions effectively.
  • Understanding factors influencing medication duration is key to improving patient outcomes.
  • Buprenorphine transdermal system (BTDS) persistence requires investigation to optimize treatment.

Purpose of the Study:

  • To analyze patient factors associated with buprenorphine transdermal system (BTDS) persistence.
  • To identify predictors of early discontinuation versus long-term adherence to BTDS therapy.

Main Methods:

  • Utilized a large US claims database (IMS Private Practitioner Medical Claims and Pharmacy Claims).
  • Identified patients initiating BTDS between January 1, 2011, and November 30, 2011.
  • Assessed preindex factors (comorbidities, prior medication use) and postindex patterns (concomitant medications, dose adjustments) to measure persistence.

Main Results:

  • 10,457 patients initiating BTDS were analyzed.
  • Prior opioid and adjuvant analgesic use were associated with decreased BTDS discontinuation (21% and 5% less likely, respectively).
  • Concomitant adjuvant analgesic use and dose adjustments were linked to longer BTDS persistence.

Conclusions:

  • Prior and concomitant use of adjuvant analgesics, prior opioid use, and dose adjustments significantly predict longer BTDS persistence.
  • Healthcare providers considering patient history and dose titration can improve early BTDS adherence.
  • Optimizing treatment strategies based on patient profiles can enhance therapy effectiveness for chronic pain.