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Related Experiment Video

Updated: May 3, 2026

Wild-type Blocking PCR Combined with Direct Sequencing as a Highly Sensitive Method for Detection of Low-Frequency Somatic Mutations

Wild-type Blocking PCR Combined with Direct Sequencing as a Highly Sensitive Method for Detection of Low-Frequency Somatic Mutations

Published on: March 29, 2017

CD79B and MYD88 mutations in diffuse large B-cell lymphoma.

Yuil Kim¹, Hyunjeong Ju², Dong Hoon Kim³

¹Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, 135-710.

Human Pathology

|January 22, 2014

Summary

Mutations in CD79B and MYD88 are common in Asian diffuse large B cell lymphoma (DLBCL) patients, particularly older individuals. These genetic alterations, while overlapping, do not significantly impact patient survival outcomes.

Keywords:

CD79B Diffuse large B cell lymphoma MYD88 Mutation

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Last Updated: May 3, 2026

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Published on: November 1, 2011

Area of Science:

Oncology
Genetics
Molecular Biology

Background:

Mutations in CD79B and MYD88, key components of the nuclear factor κB (NF-κB) pathway, are implicated in malignant lymphoma.
Understanding these mutations is crucial for developing targeted therapies.

Purpose of the Study:

To investigate the prevalence and clinicopathologic characteristics of CD79B and MYD88 mutations in Asian patients with diffuse large B cell lymphoma (DLBCL).

Main Methods:

Sanger sequencing was used to analyze CD79B and MYD88 mutations in 187 DLBCL tissue samples.
Cell-of-origin was determined using immunohistochemical stains and Hans' algorithm.

Main Results:

CD79B mutations were found in 8.5% of cases, and MYD88 L265P mutations in 19.3% of cases.
A significant overlap was observed between CD79B and MYD88 mutations (36% of MYD88 mutants).
Mutations in both genes were associated with an older age at onset but did not significantly affect patient survival.

Conclusions:

CD79B and MYD88 mutations are prevalent in Asian DLBCL patients and are linked to older age at diagnosis.
The co-occurrence of these mutations is common, but they do not serve as significant prognostic indicators for disease outcome.