Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

1.5K
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
1.5K
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

1.8K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.8K
Upper GI Series: Barium Swallow01:24

Upper GI Series: Barium Swallow

2.6K
The Barium Swallow Study, or a Barium Esophagogram, is a diagnostic imaging method used to visualize the upper gastrointestinal (GI) tract, including the esophagus, stomach, and small intestine. It employs barium sulfate, a radiopaque contrast material, to provide clear images of the upper digestive system, helping to identify abnormalities, diseases, or structural issues.
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
2.6K
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

1.1K
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
1.1K
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

1.3K
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
1.3K
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

46
Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
46

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Annotation-free learning of plankton for classification and anomaly detection.

Scientific reports·2020
Same author

Development of a method for detecting trace metals in aqueous solutions based on the coordination chemistry of hexahydrotriazines.

The Analyst·2015
See all related articles

Related Experiment Video

Updated: May 3, 2026

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells
08:54

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

13.1K

Common questions about Barrett esophagus.

Thomas G Zimmerman1

  • 1New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, USA.

American Family Physician
|January 22, 2014
PubMed
Summary
This summary is machine-generated.

Barrett esophagus, a precancerous esophageal condition, carries a small annual risk of progressing to esophageal cancer, especially with high-grade dysplasia. Management strategies, including surveillance endoscopy, are debated but recommended for high-risk individuals.

More Related Videos

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
06:55

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Published on: May 11, 2014

10.5K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

974

Related Experiment Videos

Last Updated: May 3, 2026

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells
08:54

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

Published on: July 20, 2014

13.1K
Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
06:55

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging

Published on: May 11, 2014

10.5K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

974

Area of Science:

  • Gastroenterology
  • Oncology
  • Gastrointestinal Pathology

Background:

  • Barrett esophagus is a precancerous metaplasia of the esophagus.
  • It is associated with chronic reflux but can occur without symptoms.
  • Risk factors include smoking, male sex, obesity, white race, hiatal hernia, and age over 50.

Purpose of the Study:

  • To review the risk factors, progression, and management of Barrett esophagus.
  • To discuss the role of screening and surveillance endoscopy.
  • To evaluate treatment options for dysplasia.

Main Methods:

  • Literature review of Barrett esophagus management and progression.
  • Analysis of risk factors and incidence of esophageal adenocarcinoma.
  • Discussion of endoscopic surveillance and treatment modalities.

Main Results:

  • The annual incidence of progression to esophageal cancer is 0.12%–0.33%.
  • Progression is higher in patients with high-grade dysplasia and long-segment Barrett esophagus.
  • Screening endoscopy is advised for multiple risk factors; high-grade dysplasia warrants endoscopic resection.

Conclusions:

  • Management and surveillance of Barrett esophagus remain debated.
  • Endoscopic surveillance is an option for nondysplastic Barrett esophagus.
  • Proton pump inhibitors manage symptoms but do not prevent neoplastic progression.