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Updated: May 3, 2026

Preoxygenation Techniques for Tracheal Intubation in Critically Ill Adults Utilizing Oxygen Mask and Noninvasive Ventilation
Published on: December 5, 2025
Intraoperative prophylactic and therapeutic non-invasive ventilation: a systematic review
L Cabrini1, L Nobile, V P Plumari
1Department of Anesthesia and Intensive Care, San Raffaele Scientific Institute, Ospedale San Raffaele, Via Olgettina 60, Milano 20132, Italy.
Non-invasive ventilation (NIV) is safe and feasible for preventing or treating acute respiratory failure during surgery. It is particularly useful when avoiding tracheal intubation, but more randomized studies are needed.
Area of Science:
- Anesthesiology
- Critical Care Medicine
- Respiratory Medicine
Background:
- Non-invasive ventilation (NIV) is established for perioperative acute respiratory failure (ARF).
- Intraoperative NIV may benefit patients with difficult weaning, those refusing intubation, or requiring deep sedation.
- NIV use during surgery warrants further investigation.
Purpose of the Study:
- To evaluate the feasibility and safety of intraoperative non-invasive ventilation (NIV).
- To assess the efficacy of prophylactic and therapeutic intraoperative NIV.
- To identify patient populations that may benefit from intraoperative NIV.
Main Methods:
- A systematic review of studies using PubMed, Embase, Google Scholar, and Cochrane Library.
- Inclusion criteria: intraoperative NIV in adult patients; exclusion criteria: preoperative/postoperative use, pediatric patients, negative pressure ventilation.
- Analysis of 30 papers including 618 patients.
Main Results:
- Therapeutic intraoperative NIV for ARF in 92 patients, including 6 C-sections, resulted in uneventful surgeries.
- Prophylactic intraoperative NIV for 24 patients with respiratory limitation and 502 healthy patients under deep sedation was successful.
- Three cases of upper airway obstruction occurred, but no further complications were reported.
Conclusions:
- Intraoperative NIV appears feasible and safe for selected adult patients.
- NIV may be particularly beneficial when avoiding tracheal intubation is desired.
- High-quality randomized controlled trials are necessary to confirm these findings.
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