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Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

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Fabrication of solid lipid microcapsules containing ascorbic acid using a microfluidic technique.

Talita A Comunian¹, Alireza Abbaspourrad², Carmen S Favaro-Trindade¹

¹Universidade de São Paulo, Faculdade de Zootecnia e Engenharia de Alimentos, Av. Duque de Caxias Norte, 225, CP 23, CEP 13535 900 Pirassununga, São Paulo, Brazil.

|January 22, 2014

Summary

This summary is machine-generated.

Researchers developed stable, microencapsulated ascorbic acid (Vitamin C) using microfluidic technology. This innovation protects the vitamin in food products and masks its sour taste.

Keywords:

Encapsulation Encapsulation efficiency Lipid shell Vitamin C

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Area of Science:

Food Science
Materials Science
Chemical Engineering

Background:

Ascorbic acid (AA), or Vitamin C, is essential in human diets.
AA fortification in foods is desirable but challenging due to its instability.
Developing stable delivery systems for AA is a key research area.

Purpose of the Study:

To create solid lipid microcapsules (SLMs) encapsulating ascorbic acid using microfluidic technology.
To enhance the encapsulation efficiency and stability of AA within the SLMs.
To evaluate the potential of SLMs as a vehicle for AA in food products.

Main Methods:

Utilized microfluidic technology to fabricate solid lipid microcapsules (SLMs).
Employed optical, scanning electron, and confocal microscopy for morphological analysis.
Investigated pore blocking and micromolecule-chelating agents to improve AA encapsulation and stability.
Determined encapsulation efficiency, particle size, and stability of the encapsulated AA.

Main Results:

Successfully produced AA-loaded SLMs with controlled morphology.
Achieved enhanced encapsulation efficiency and stability of AA using the developed methods.
Demonstrated the potential of SLMs to prevent AA degradation in food matrices.
Observed that the SLMs could effectively mask the acidic taste of AA.

Conclusions:

Microfluidic technology offers a promising approach for creating stable AA-loaded SLMs.
The developed SLMs show significant potential for fortifying food products with AA.
This encapsulation method addresses the instability and taste challenges associated with incorporating AA into foods.