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Published on: December 23, 2016
Amphiphilic chitosan derivative-based core-shell micelles: synthesis, characterisation and properties for sustained
Wenjian Li1, Hailong Peng2, Fangjian Ning1
1State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China.
Abstract:
Novel amphiphilic chitosan derivative of N,N-dimethylhexadecyl carboxymethyl chitosan (DCMCs) was synthesised. The physical properties of DCMCs were characterised by Fourier transform-infrared spectroscopy, nuclear magnetic resonance spectroscopy, X-ray diffraction and differential scanning calorimetry. DCMCs can form core-shell micelles with low critical micelle concentration (31 mg L(-1)). The core-shell micelles exhibited spherical shape with positive charge (+50.7 mV) and narrow size distribution (polydispersity index <0.5). Vitamin D3 (VD3) was initially used to load into the core-shell micelles, and the solubility of VD3 was improved with higher encapsulation efficiency (53.2%). The in vitro release processes of VD3 from the core-shell micelles were initially rapid and then followed by a sustained release. The Higuchi model was the most suitable for describing the entire release procedure. DCMCs core-shell micelles are promising carriers for VD3 and other hydrophobic bioactive food factors.
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