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Exercise modifies amphetamine relapse: behavioral and oxidative markers in rats.

H J Segat¹, M Kronbauer¹, Kr Roversi²

¹Programa de Pós-Graduação em Bioquímica Toxicológica-Universidade Federal de Santa Maria-UFSM-RS, Brazil.

Behavioural Brain Research

|January 22, 2014

Summary

Physical exercise can prevent addictive drug relapse by improving brain neurochemistry. This study found exercise reduced amphetamine-induced relapse behaviors and anxiety in rats, normalizing biochemical markers in the hippocampus.

Keywords:

Amphetamine Physical exercise Psychostimulants Relapse

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Area of Science:

Neuroscience
Pharmacology
Exercise Physiology

Background:

Addictive drugs can alter brain neuroplasticity and neurotransmission, leading to rewarding symptoms.
Physical exercise is known to influence neurobiological pathways potentially relevant to addiction.

Purpose of the Study:

To investigate the effects of physical exercise on behavioral and enzymatic markers associated with amphetamine (AMPH) relapse in a rat model.
To determine if exercise can mitigate drug-seeking behavior and anxiety-like symptoms post-abstinence.

Main Methods:

Rats received amphetamine or vehicle in a conditioned place preference (CPP) paradigm, followed by a 5-week swimming exercise intervention.
Drug relapse and anxiety-like behaviors were assessed upon re-exposure to the CPP paradigm and via the elevated plus maze (EPM).
Biochemical analyses of the hippocampus were performed to evaluate oxidative stress markers and enzyme activity.

Main Results:

Amphetamine exposure induced place preference and anxiety, indicative of addiction and withdrawal.
Exercise significantly prevented relapse behaviors and reduced anxiety-like symptoms after amphetamine reconditioning.
Exercise normalized amphetamine-induced increases in reactive species and protein carbonyls, and restored catalase and Na(+)K(+)-ATPase activity in the hippocampus.

Conclusions:

Physical exercise demonstrates a significant beneficial effect in preventing psychostimulant drug relapse.
Exercise mitigates behavioral and neurochemical consequences of amphetamine exposure, suggesting a protective role against addiction.
Exercise normalizes hippocampal oxidative stress and enzyme function, contributing to the prevention of drug relapse.