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Upper airway cough syndrome in children and two inflammatory factors: TRPV1 and TGF-β2

Ying-Xia Lu1, Qing-Long Gu1, Jun Du1

  • 1Department of Otolaryngology-Head and Neck Surgery, Capital Institute of Pediatrics affiliated children's hospital, Beijing, China.

International Journal of Pediatric Otorhinolaryngology
|January 22, 2014
PubMed

Insights

Elevated TRPV1 and TGF-β2 levels in children indicate upper airway cough syndrome (UACS). This study explored these inflammatory factors and identified tonsil hypertrophy as a risk factor for UACS.

Area of Science:

  • Pediatric Otolaryngology
  • Immunology
  • Respiratory Medicine

Background:

  • Upper airway cough syndrome (UACS) is a common cause of chronic cough in children.
  • The role of specific inflammatory markers like TRPV1 and TGF-β2 in UACS pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate upper airway cough syndrome (UACS) in children.
  • To explore the relationships among TRPV1, TGF-β2, and UACS.
  • To identify potential diagnostic markers and risk factors for UACS in pediatric patients.

Main Methods:

  • 104 children (aged 2-13) with adenoid hypertrophy were included.
  • Enzyme-linked immunosorbent assay (ELISA) and immunohistochemical (IHC) studies were performed for TRPV1 and TGF-β2.
  • Correlations between inflammatory markers, clinical factors, and UACS diagnosis were analyzed across three study stages.

Main Results:

  • TRPV1 and TGF-β2 levels were significantly elevated in children with UACS.
  • Obstructive sleep apnea-hypopnea syndrome (OSAHS) and thick mucus secretions correlated with UACS diagnosis.
  • Asthma history and thick mucus secretions were associated with increased inflammatory factor levels.

Conclusions:

  • Serum and adenoid body detection of TRPV1 and TGF-β2 can aid in auxiliary diagnosis of UACS.
  • Tonsil hypertrophy and a history of chronic tonsillitis are identified as independent risk factors for UACS in children.
Abstract

Keywords:
Airway sensitivityChronic inflammationCoughingRespiratory symptomsTGF-β2Transient receptor potential (TRP) ion channels

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