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Updated: May 3, 2026
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Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
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High sputum total adiponectin is associated with low odds for asthma
Akshay Sood1, JeanClare Seagrave, Guy Herbert
1School of Medicine, University of New Mexico , Albuquerque, NM , USA .
Summary
High levels of sputum adiponectin, an anti-inflammatory protein, were linked to a reduced risk of asthma. This finding suggests potential new avenues for asthma prevention and treatment.
Area of Science:
- Pulmonary Medicine
- Immunology
- Biochemistry
Background:
- Adipose tissue secretes adiponectin, an anti-inflammatory protein.
- Elevated systemic adiponectin levels correlate with decreased asthma risk.
- The relationship between lung-specific adiponectin and asthma remains unclear.
Purpose of the Study:
- To investigate the association between sputum adiponectin levels and asthma.
- To compare sputum adiponectin in asthma patients versus healthy controls.
Main Methods:
- A case-control study involving 44 asthma patients and 44 matched controls.
- Quantification of serum and sputum adiponectin using ELISA and Western Blot.
- Statistical analyses included t-tests, Spearman correlations, and regression models.
Main Results:
- Medium-molecular-weight adiponectin was predominant in sputum, unlike serum.
- Sputum adiponectin levels were lower in asthma patients compared to controls (p=0.03).
- Higher sputum adiponectin was associated with reduced asthma odds (OR 0.33), independent of BMI and serum adiponectin.
Conclusions:
- Elevated sputum total adiponectin is a predictor of lower asthma risk, even when accounting for systemic factors.
- These findings may open new therapeutic strategies targeting sputum adiponectin for asthma management.
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