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The flavonoid quercetin inhibits thyroid-restricted genes expression and thyroid function.

Cesidio Giuliani1, Ines Bucci1, Serena Di Santo2

  • 1Unit of Endocrinology, Department of Medicine and Sciences of Aging, 'G. D'Annunzio' University of Chieti-Pescara, via dei Vestini, 66100 Chieti, Italy; Aging Research Center (Ce.S.I.), 'G. D'Annunzio' University Foundation, via L. Polacchi 11/17, 66100 Chieti, Italy.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|January 23, 2014
PubMed
Summary

Quercetin, found in fruits and vegetables, may disrupt thyroid function. This study shows quercetin decreases key thyroid gene expression and reduces radioiodine uptake in rats, suggesting caution with supplements.

Keywords:
Endocrine disruptorFRTL-5QuercetinRadioiodide uptakeRatThyroid

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Area of Science:

  • Endocrinology
  • Nutritional Science
  • Toxicology

Background:

  • Quercetin is a prevalent flavonoid in fruits and vegetables, also available as a dietary supplement.
  • Quercetin possesses antioxidant, antiproliferative, and anti-inflammatory properties.
  • Concerns exist regarding potential toxicity from excessive quercetin intake, particularly its interference with thyroid function.

Purpose of the Study:

  • To investigate the effects of quercetin on the expression of thyroid-restricted genes.
  • To evaluate the in vivo impact of quercetin on thyroid function.

Main Methods:

  • Assessed the impact of quercetin on the expression of thyrotropin receptor, thyroid peroxidase, and thyroglobulin genes.
  • Measured radioiodine uptake in Sprague-Dawley rats following 14 days of quercetin treatment.

Main Results:

  • Quercetin significantly decreased the expression of thyrotropin receptor, thyroid peroxidase, and thyroglobulin genes.
  • In vivo studies demonstrated a significant reduction in radioiodine uptake in rats treated with quercetin.

Conclusions:

  • Quercetin acts as a thyroid disruptor.
  • Caution is advised regarding the supplemental and therapeutic use of quercetin due to its potential to interfere with thyroid function.