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Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
Published on: July 18, 2016
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Thrombosis in ovarian cancer: a case control study
R L Metcalf1, D J Fry1, R Swindell1
1Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK.
British Journal of Cancer
|January 23, 2014
Summary
Thrombotic events are common in ovarian cancer patients, occurring in 21.6%. While associated with poorer survival, this link disappears when considering prognostic factors like performance status and FIGO stage.
Area of Science:
- Oncology
- Hematology
- Clinical Medicine
Background:
- Thrombotic events are frequent in cancer patients.
- These events are linked to poor prognosis in registry studies.
Purpose of the Study:
- To determine the incidence and risk factors of thrombotic events in ovarian cancer patients.
- To evaluate the prognostic impact of thrombosis in this population.
Main Methods:
- Retrospective cohort study of 417 ovarian cancer patients (2006-2009).
- Outcomes compared to a matched control group without thrombosis.
- Analysis included incidence, risk factors, and survival impact.
Main Results:
- 21.6% of patients experienced thrombotic events.
- Thrombosis associated with older age, worse performance status (PS), and advanced FIGO stage.
- Pulmonary embolism and deep vein thrombosis linked to shorter survival initially.
Conclusions:
- Ovarian cancer patients with thrombosis had shorter survival.
- When matched for performance status and FIGO stage, thrombosis did not significantly impact prognosis.
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