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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
High prevalence and risk factors for kidney dysfunction in patients with atherosclerotic cardio-cerebrovascular
1From the Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin 150001, China.
Insights
Kidney dysfunction is common in patients with cardio-cerebrovascular disease. Key risk factors include diabetes mellitus, hypertension, and elevated serum uric acid, highlighting the need for early identification and management.
Area of Science:
- Cardiology
- Nephrology
- Epidemiology
Background:
- Cardio-cerebrovascular disease (CCVD) patients face elevated kidney dysfunction risk due to shared risk factors.
- Understanding kidney dysfunction prevalence and characteristics in CCVD is crucial for risk stratification.
Purpose of the Study:
- To determine the prevalence and characteristics of kidney dysfunction in patients with CCVD.
- To identify significant risk factors associated with kidney dysfunction in this high-risk population.
Main Methods:
- Evaluated renal function in 1012 patients diagnosed with CCVD.
- Conducted univariate and multivariable analyses to identify risk factors for reduced kidney function.
Main Results:
- Univariate analysis identified age, gender, hypertension, diabetes mellitus, dyslipidemia, and serum uric acid as risk factors.
- Multivariable analysis confirmed diabetes mellitus (OR 1.609), hypertension (OR 1.547), and serum uric acid (OR 1.009) as independent predictors of reduced kidney function.
- 25.6% of patients with both hypertension and diabetes mellitus exhibited significantly decreased estimated glomerular filtration rate (eGFR).
Conclusions:
- Kidney dysfunction is prevalent in patients with CCVD.
- Patients with CCVD and any stage of kidney dysfunction represent a high-risk group requiring close monitoring.
- Early recognition and management of kidney dysfunction in CCVD patients are essential for improving outcomes.
Background:
Patients with atherosclerotic cardio-cerebrovascular disease are at high risk of kidney dysfunction because of the overlap of several risk factors. The purpose of this study is to examine the prevalence and characteristics and risk factors for kidney dysfunction in the cardio-cerebrovascular disease population.
Methods:
Renal functions of 1012 patients with the cardio-cerebrovascular disease were evaluated with the purpose of evaluating characteristics of the incidence, risk factors for kidney dysfunction in the cardio-cerebrovascular disease population.
Results:
In the univariate analysis, the major risk factors for kidney dysfunction in the patients with the cardio-cerebrovascular disease were age, gender, hypertension, diabetes mellitus, dyslipidemia and serum uric acid. In the patients with both hypertension and diabetes mellitus the percentages of significantly decreased eGFR were 25.6%. Results of multivariable analysis showed that diabetes mellitus (odds ratio (OR) 1.609, 95% confidence intervals (CI) 1.08-2.398, P = 0.019), hypertension (OR 1.547, 95% CI 1.049-2.281, P = 0.028) and serum uric acid (OR 1.009, 95% CI 1.007-1.010, P < 0.001) were independent risk factors for reduced kidney function.
Conclusions:
In the context of the cardio-cerebrovascular disease kidney dysfunction is common and has a high prevalence. Patients with both cardio-cerebrovascular disease and kidney dysfunction at any stage should be recognized as high-risk population.
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