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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
Inhibition of theophylline metabolism by interferon
S J Williams1, J A Baird-Lambert, G C Farrell
1Department of Medicine, University of Sydney, NSW, Australia.
Abstract:
1 day after a single intramuscular injection of recombinant human interferon alpha A in 5 patients with stable chronic active hepatitis B and 4 healthy controls theophylline clearance was significantly reduced and theophylline elimination half-life was significantly increased. There was a clear relation between pre-treatment and post-treatment theophylline clearance rates, indicating that the greatest effect of interferon was in subjects who were fast metabolisers of theophylline. These observations support the contention that the actions of endogenous interferon may account for the effects of immunisations and viral infections on hepatic drug metabolism. Moreover, treatment with interferon may cause clinically important drug interactions.
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