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Related Concept Videos

Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

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Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

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Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Chronic Salmonella Infection Induced Intestinal Fibrosis
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[Genome-associated studies in chronic inflammatory dermatoses].

E Rodríguez1, S Weidinger

  • 1Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 7, 24105, Kiel, Deutschland.

Der Internist
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Summary

Atopic eczema and psoriasis vulgaris are common chronic skin diseases influenced by genetics and environment. Genetic research is improving understanding and leading to new treatments for these inflammatory conditions.

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Area of Science:

  • Dermatology
  • Genetics
  • Immunology

Context:

  • Atopic eczema and psoriasis vulgaris are prevalent chronic inflammatory skin diseases.
  • These conditions are multifactorial, influenced by genetic and environmental interactions.
  • Recent technological advancements have significantly enhanced understanding of their genetic basis.

Purpose:

  • To explore the genetic architecture of atopic eczema and psoriasis vulgaris.
  • To identify genetic risk factors and understand disease pathophysiology.
  • To translate genetic knowledge into clinical applications for patient stratification and novel therapeutics.

Summary:

  • Genome-wide association studies have revealed numerous genetic risk factors for atopic eczema and psoriasis vulgaris.
  • Genetic epidemiology provides insights into disease mechanisms and pathophysiology.
  • New sequencing and systems biology approaches offer further understanding of genetic roles in chronic inflammatory skin diseases.

Impact:

  • Improved patient stratification using genetic markers.
  • Development of innovative therapeutic strategies targeting identified pathways.
  • Enhanced comprehension of the genetic underpinnings of chronic inflammatory dermatoses.