Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

3.0K
3.0K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.5K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.5K
Cellular Injury V: Apoptosis and Autophagy01:22

Cellular Injury V: Apoptosis and Autophagy

99
Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
99
Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

3.9K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.9K
Cellular Injury IlI: Cellular Death01:11

Cellular Injury IlI: Cellular Death

70
Cell death is the irreversible loss of cellular structure and function, representing the final stage of severe injury. It plays a key role in both normal physiology and disease.Types of Cell DeathThe two main types are necrosis and apoptosis, though others like necroptosis and pyroptosis also exist.Necrosis:Necrosis is an unregulated form of cell death caused by severe injury such as trauma, toxins, or ischemia. It is characterized by cell swelling, membrane loss, rupture, and leakage of...
70
Negative Regulator Molecules01:23

Negative Regulator Molecules

32.1K
Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
32.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Scrub Typhus Presenting with Isolated Xerostomia.

The American journal of tropical medicine and hygiene·2026
Same author

Causal inference and digital twins: a roadmap for the future of clinical trials.

NPJ digital medicine·2026
Same author

Senescent Human Liver Endothelial Cells Mediate CD4<sup>+</sup> T Cell Recruitment via ICOSL.

Immunology·2026
Same author

Post-pandemic surge in invasive group A Streptococcus infections: A hospital-based active surveillance study in Okinawa, Japan.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2026
Same author

Author Correction: Titration of RAS alters senescent state and influences tumour initiation.

Nature·2026
Same author

Complete genome analysis of <i>Edwardsiella tarda</i> strain MYK24826 isolated from a Japanese patient with prosthetic valve endocarditis.

Microbiology resource announcements·2026

Related Experiment Video

Updated: May 3, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

34.3K

Cellular senescence and its effector programs.

Rafik Salama1, Mahito Sadaie, Matthew Hoare

  • 1Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom;

Genes & Development
|January 23, 2014
PubMed
Summary

Cellular senescence, a cell cycle exit response, involves multiple pathways and effectors. This review discusses key senescence effectors and their functional links, including the senescence-associated secretory phenotype (SASP).

Keywords:
DNA damageaginginflammationmetabolismoncogenessenescencetumor suppressors

More Related Videos

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.2K
SA-&#946;-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

23.5K

Related Experiment Videos

Last Updated: May 3, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

34.3K
Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.2K
SA-&#946;-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

23.5K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Gerontology

Background:

  • Cellular senescence is a stress-induced cell cycle arrest.
  • Key pathways involved include p53 and p16/Rb tumor suppressors.
  • Senescence is a complex phenotype driven by multiple effector mechanisms.

Purpose of the Study:

  • To discuss key features of senescence effectors.
  • To functionally link these effectors where possible.
  • To highlight the diverse nature of senescence.

Main Methods:

  • Literature review and synthesis of existing studies on cellular senescence.
  • Analysis of effector mechanisms and their interplay.
  • Focus on the senescence-associated secretory phenotype (SASP).

Main Results:

  • Senescence is characterized by a collective phenotype of multiple effectors.
  • The intensity and combination of effectors vary with triggers and cell types.
  • The senescence-associated secretory phenotype (SASP) has diverse in vivo functions.

Conclusions:

  • Senescence is a multifaceted process with diverse effector mechanisms.
  • Understanding these effectors and their functional links is crucial.
  • Further research can elucidate the complex roles of senescence in health and disease.