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Updated: May 3, 2026
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Quantitative assessment of left ventricular function by 3-dimensional speckle-tracking echocardiography in patients
Chunyan Ma1, Jiang Chen, Jun Yang
1Department of Cardiovascular Ultrasound, First Affiliated Hospital of China Medical University, 115 Nanjing St, Heping District, 110001 Shenyang, China. cmu1h_mcy@126.com.
Insights
Three-dimensional (3D) speckle-tracking echocardiography effectively assesses left ventricular (LV) function in chronic heart failure (CHF) patients. This noninvasive method objectively measures LV ejection fraction, volumes, and strain, distinguishing patients from healthy controls.
Area of Science:
- Cardiology
- Medical Imaging
- Echocardiography
Background:
- Left ventricular (LV) dysfunction is a hallmark of chronic heart failure (CHF).
- Accurate, noninvasive assessment of LV function is crucial for managing CHF patients.
- Traditional echocardiography has limitations in fully characterizing complex LV mechanics.
Purpose of the Study:
- To evaluate the clinical utility of 3D speckle-tracking echocardiography (3DSTE) for assessing LV function in CHF.
- To determine if 3DSTE can differentiate LV function parameters between CHF patients and healthy controls.
- To provide a meta-analysis of existing studies on 3DSTE in CHF.
Main Methods:
- A systematic literature search was performed across major databases (PubMed, Embase, Web of Science, China BioMedicine) up to October 2012.
- Seven case-control studies involving 375 CHF patients and 181 healthy controls were included.
- Meta-analysis calculated standardized mean differences and 95% confidence intervals for various LV function parameters.
Main Results:
- CHF patients exhibited significantly lower LV ejection fraction compared to controls.
- Patients showed significantly higher LV end-diastolic volume (LVEDV) and LV end-systolic volume (LVESV).
- Impaired global longitudinal, circumferential, and radial strain were observed in CHF patients, alongside delayed regional wall motion.
Conclusions:
- 3D speckle-tracking echocardiography provides a noninvasive and objective method for evaluating LV function in patients with CHF.
- 3DSTE can detect significant abnormalities in LV systolic function and mechanics in CHF.
- This technique holds clinical utility for the assessment and management of chronic heart failure.
Objectives:
To provide a comprehensive analysis of the clinical utility of 3-dimensional (3D) speckle-tracking echocardiography for left ventricular (LV) function in patients with chronic heart failure (CHF).
Methods:
Literature searches were conducted in the PubMed, Embase, Web of Science, and China BioMedicine databases on relevant articles published before October 1, 2012. Crude standardized mean differences with 95% confidence intervals (CIs) were calculated.
Results:
Seven case-control studies were included with a total of 375 patients with CHF and 181 healthy control participants. Meta-analysis results showed that the LV ejection fraction in the patients was significantly lower than in the controls (standardized mean difference, -4.62; 95% CI, -6.19 to -3.04), whereas the LV end-diastolic volume (LVEDV) and LV end-systolic volume (LVESV) in the patients were higher than in the controls (LVEDV: standardized mean difference, 1.76; 95% CI, 1.09 to 2.44; LVESV: standardized mean difference, 2.04, 95% CI, 1.30 to 2.78). The results also indicated that the patients had a greater delay in the standard deviation of the time to peak area tracking and the maximum difference in the time to peak area tracking in the 16 LV segments than the controls (standard deviation of the time to peak area tracking: standardized mean difference, 3.01; 95% CI, 1.73 to 4.29; maximum difference in the time to peak area tracking: standardized mean difference, 3.26; 95% CI, 1.58 to 4.93). Furthermore, global longitudinal, circumferential, and radial strain were also significantly impaired in the patients compared to the controls (longitudinal strain: standardized mean difference, 2.75; 95% CI, 1.11 to 4.39; circumferential strain: standardized mean difference, 2.71; 95% CI, 1.15 to 4.27; radial strain: standardized mean difference, 1.80; 95% CI, 0.45 to 3.14).
Conclusions:
This meta-analysis suggests that LV function in patients with CHF can be noninvasively and objectively measured by 3D speckle-tracking echocardiography.
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