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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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Brain functional connectivity and morphology changes in medication-overuse headache: Clue for dependence-related
S Chanraud1, G Di Scala2, B Dilharreguy2
1Bordeaux University, CNRS, INCIA, France EPHE, France sandra.chanraud@u-bordeaux1.fr.
Cephalalgia : an International Journal of Headache
|January 23, 2014
Summary
Medication-overuse headache (MOH) is linked to altered brain connectivity, not structural changes. Dependence factors may influence MOH development and maintenance, impacting brain networks.
Area of Science:
- Neuroimaging
- Neurology
- Brain Connectivity
Background:
- Medication-overuse headache (MOH) is associated with localized brain changes.
- Previous studies indicate both anatomical and functional alterations in MOH.
Purpose of the Study:
- To investigate whole-brain functional connectivity and voxel-based morphometry in MOH patients.
- To compare these findings with episodic migraine (EM) and healthy controls (HCs).
Main Methods:
- Anatomical and resting-state functional MRI scans were acquired from MOH, EM, and HC groups.
- SPM8 software was used for voxel-based morphometry and seed-to-voxel connectivity analysis.
Main Results:
- MOH patients exhibited altered resting-state functional connectivity, with decreased precuneus connectivity to the default-mode network and increased connectivity to hippocampal/temporal areas.
- These functional changes were not associated with significant gross morphological differences.
- Connectivity alterations correlated with migraine duration and medication dependence, while gray matter volumes related to migraine duration.
Conclusions:
- MOH is characterized by functional brain network alterations rather than macrostructural changes.
- Dependence-related processes appear crucial in the development and maintenance of MOH.
- Functional connectivity and gray matter volumes may predict anxiety and depression scores in MOH patients.
Keywords:
Migrainedefault mode networkfMRIhippocampusorbitofrontal cortexprecuneusvoxel-based morphometryMore Related Videos
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