[Association of YWHAE gene polymorphism with suicidal behavior].

Area of Science:

• Genetics
• Psychiatry
• Behavioral Science

Background:

• Suicidal behavior is a complex issue with multifactorial causes.
• Genetic predisposition is increasingly recognized as a significant contributing factor.
• The YWHAE gene has been implicated in various neurological and psychiatric conditions.

Purpose of the Study:

• To investigate the association between specific YWHAE gene polymorphisms (rs1532976, rs3752826, rs9393) and suicidal behavior.
• To examine these associations in Russian and Tatar ethnic groups from the Republic of Bashkortostan.
• To identify potential genetic markers for suicidal behavior risk.

Main Methods:

• Case-control study design.
• Genotyping of YWHAE gene polymorphisms (rs1532976, rs3752826, rs9393) using established molecular techniques.
• Statistical analysis including odds ratios (OR) to assess the risk associated with specific alleles and genotypes.

Main Results:

• The YWHAE*C allele of the rs3752826 polymorphism was associated with an increased risk of suicidal behavior (OR = 1.91) irrespective of ethnicity.
• In the Russian ethnic group, the YWHAE*T allele of rs9393 (OR = 2.21), the YWHAE*T/*T genotype of rs1532976 (OR = 2.73), and the YWHAE*T allele of rs1532976 (OR = 1.52) were identified as genetic risk markers.
• A haplotype analysis revealed that the YWHAE*A*T haplotype of rs1532976 and rs9393 polymorphisms was also associated with an elevated risk of suicidal behavior in the Russian sample (OR = 1.54).

Conclusions:

• Specific polymorphisms and alleles within the YWHAE gene are associated with an increased risk of suicidal behavior.
• The rs3752826 polymorphism shows an ethnicity-independent association with suicidal behavior risk.
• Certain YWHAE gene variations serve as significant genetic markers for suicidal behavior risk, particularly in the Russian ethnic group.