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Vitamin D concentrations in familial combined hyperlipidemia: effects of lipid lowering treatment

Inka Miñambres, Jose Luis Sánchez-Quesada, Joan Sánchez-Hernández

  • 1Endocrinology and Nutrition Department, Hospital de la Santa Creu i Sant Pau, C/Sant Antoni Maria Claret 167, 08025 Barcelona, Spain. aperez@santpau.cat.

Diabetology & Metabolic Syndrome
|January 24, 2014
PubMed

Insights

Familial combined hyperlipidemia (FCHL) is associated with lower vitamin D levels. Lipid-lowering therapy improved vitamin D status in FCHL patients, suggesting a link between dyslipidemia and vitamin D.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Nutritional Science

Background:

  • Vitamin D deficiency is linked to cardiovascular risk factors.
  • Limited data exists on vitamin D levels in familial combined hyperlipidemia (FCHL).

Purpose of the Study:

  • To investigate vitamin D concentrations in FCHL patients.
  • To assess the impact of lipid-lowering therapy on vitamin D levels in FCHL.

Main Methods:

  • Cross-sectional study comparing 59 FCHL patients to 48 controls.
  • Analysis of 25-hydroxyvitamin D (25(OH)D) and its association with lipid profiles, anthropometrics, CRP, and HOMA.
  • Longitudinal study of 23 FCHL patients before and after dyslipidemia treatment.

Main Results:

  • FCHL patients had significantly lower vitamin D concentrations than controls after adjustments.
  • Hypovitaminosis D in FCHL correlated with atherogenic dyslipidemia features.
  • Lipid-lowering therapy increased vitamin D levels in FCHL patients (P=0.022).

Conclusions:

  • FCHL is associated with reduced vitamin D concentrations.
  • Dyslipidemia treatment appears to improve vitamin D status in FCHL patients.
  • Further research is needed to confirm findings and understand underlying mechanisms.
Abstract

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