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The potential to predict the course of childhood asthma

Daniel W Belsky1, Malcolm R Sears

  • 1Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27708, USA.

Expert Review of Respiratory Medicine
|January 24, 2014
PubMed

Insights

Predicting childhood asthma progression is crucial. Genetic information, alongside clinical and environmental factors, shows promise in identifying children at risk for persistent asthma, aiding early intervention strategies.

Area of Science:

  • Pediatric Respiratory Medicine
  • Asthma Genetics
  • Epidemiology

Background:

  • Wheezing is common in early childhood, with variable persistence into lifelong asthma.
  • Predictive tools for childhood asthma course are essential for families and clinicians.
  • Longitudinal birth-cohort studies are key to understanding asthma development.

Purpose of the Study:

  • To review risk factors for childhood asthma persistence and remission.
  • To explore the role of genetic information in predicting asthma outcomes.
  • To discuss implications for clinical practice and future research.

Main Methods:

  • Systematic review of longitudinal population-based birth-cohort studies.
  • Analysis of clinical, environmental, familial, and biomarker data.
  • Inclusion of genetic variants and polygenic risk scores.

Main Results:

  • Identified diverse risk factors including clinical, environmental, and familial elements.
  • Highlighted biomarkers of allergic inflammation and lung function measurements.
  • Recent studies suggest genetic risk scores can predict asthma course.

Conclusions:

  • A multifactorial approach is needed to predict childhood asthma.
  • Genetic information offers a promising avenue for personalized asthma prediction.
  • Further research can refine predictive models for better childhood asthma management.

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