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Use of infliximab and other biologics in Behçet disease

J Li1, S Fernando, G Herkes

  • 1Department of Clinical Immunology and Allergy, Royal North Shore Hospital, Sydney, New South Wales, Australia.

Internal Medicine Journal
|January 24, 2014
PubMed

Insights

Behçet disease, a rare vasculitis, can affect the nervous system. Tumor necrosis factor antagonists, like infliximab, show promise for treating neuro-Behçet disease, improving outcomes for affected young men.

Area of Science:

  • Immunology
  • Neurology
  • Rheumatology

Background:

  • Behçet disease is a rare multisystem vasculitis.
  • Characterized by recurrent oral ulcers and other systemic manifestations.
  • Neurological involvement, or neuro-Behçet disease, is a severe complication.

Observation:

  • Neuro-Behçet disease typically affects young men aged 20-40.
  • This condition is associated with significant long-term morbidity and mortality.
  • Case literature suggests potential treatment avenues.

Findings:

  • Tumor necrosis factor (TNF) antagonists are a potential therapeutic option.
  • Infliximab, a specific TNF antagonist, has demonstrated efficacy in case studies.
  • Evidence supports its use in managing neuro-Behçet disease.

Implications:

  • Targeted immunosuppression with TNF antagonists may alter disease course.
  • Infliximab offers a treatment strategy for severe neuro-Behçet disease.
  • Further research could solidify the role of biologics in managing this rare vasculitis.

Keywords:
Behçet diseaseinfliximabneuro-Behçet

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