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NF-κB-dependent Signaling Pathway

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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Related Experiment Video

Updated: May 3, 2026

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells

Published on: January 12, 2020

NF-κB and the cell cycle.

Adeline C Ledoux¹, Neil D Perkins¹

¹*Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, U.K.

Biochemical Society Transactions

|January 24, 2014

Summary

This summary is machine-generated.

Nuclear factor kappa B (NF-κB) regulates the cell cycle, a role often overshadowed by its inflammatory functions. This review details NF-κB

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Area of Science:

Molecular Biology
Cell Biology
Biochemistry

Background:

Nuclear factor kappa B (NF-κB) is a key transcription factor family involved in cellular responses to stimuli.
NF-κB's role in regulating inflammatory gene expression is well-established, but its involvement in cell cycle control is less explored.

Purpose of the Study:

To provide an updated review on the integration of NF-κB activity with cell cycle regulation.
To highlight newly identified direct and indirect target genes of NF-κB in cell cycle control.
To elucidate the mechanisms by which the cell cycle regulates NF-κB activity.

Main Methods:

Literature review and synthesis of existing research.
Analysis of newly characterized NF-κB target genes.
Investigation of regulatory mechanisms between NF-κB and the cell cycle.

Main Results:

NF-κB directly and indirectly influences multiple stages of the cell cycle.
Novel NF-κB target genes involved in cell cycle progression have been identified.
The cell cycle reciprocally regulates NF-κB activity through various mechanisms.

Conclusions:

NF-κB plays a significant, albeit underappreciated, role in cell cycle regulation.
Understanding this interplay is crucial for comprehending cellular responses and developing therapeutic strategies.