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Maxam-Gilbert Sequencing

Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...

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Related Experiment Video

Updated: May 3, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Programmable DNA tile self-assembly using a hierarchical sub-tile strategy.

Xiaolong Shi¹, Wei Lu, Zhiyu Wang

¹School of Automation, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China.

|January 24, 2014

Summary

This summary is machine-generated.

A new DNA sub-tile strategy simplifies the creation of complex nanostructures. This modular approach allows for rapid redesign and prototyping of programmable DNA tiles for advanced self-assembly applications.

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Area of Science:

Nanotechnology
Synthetic Biology
Biochemistry

Background:

DNA tile-based self-assembly offers a bottom-up method for creating nanostructures.
Existing methods face challenges with complex lattice designs and large tile sets.

Purpose of the Study:

To introduce a novel DNA 'sub-tile' strategy for modular tile construction.
To demonstrate the creation of programmable DNA tiles with enhanced flexibility and stability.

Main Methods:

Development of a hierarchical design using DNA sub-tiles.
Construction of 3-, 4-, and 6-arm DNA tiles.
Analysis of self-assembly using polyacrylamide gel electrophoresis and atomic force microscopy.

Main Results:

Successful demonstration of the DNA sub-tile strategy for creating diverse tile families.
Assembly of sub-tiles into 2D lattices and 3D nanotubes.
Validation of the stability and flexibility of the sub-tile approach.

Conclusions:

The sub-tile strategy provides a versatile and efficient method for DNA nanostructure fabrication.
This approach facilitates rapid redesign and prototyping of complex and asymmetric DNA tiles.
It enhances the capabilities of DNA tile self-assembly for advanced applications.