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Controllable Ion Channel Expression through Inducible Transient Transfection
Published on: February 17, 2017
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Transient receptor potential channels and occupational exposure
Pierangelo Geppetti1, Riccardo Patacchini, Romina Nassini
1aPharmacology and Oncology Unit, Department of Health Sciences, University of Florence, Florence bChiesi Farmaceutici, Parma, Italy.
Current Opinion in Allergy and Clinical Immunology
|January 24, 2014
Summary
Transient receptor potential (TRP) channels, particularly TRP ankyrin 1 (TRPA1), are key players in airway inflammation. Targeting these channels may offer new treatments for respiratory diseases like asthma and COPD.
Area of Science:
- Respiratory physiology and pathophysiology
- Neuroimmunology of airways
- Molecular mechanisms of inflammation
Background:
- Transient receptor potential (TRP) channels are expressed in airway sensory neurons and non-neuronal cells.
- Their role in respiratory tract physiology and pathology is under investigation.
Purpose of the Study:
- To understand the role of TRP channels in the respiratory tract.
- To explore the involvement of TRP channels in airway inflammation and disease.
Main Methods:
- Localization studies of TRP channels in airway neurons.
- Investigation of TRP channel activation by endogenous and environmental factors.
- Analysis of TRP channel involvement in inflammatory conditions like asthma and COPD.
Main Results:
- TRP vanilloid (TRPV1, TRPV4) and TRP ankyrin 1 (TRPA1) channels in sensory neurons promote airway neurogenic inflammation.
- TRPA1 is activated by oxidative/nitrative stress byproducts and mediates responses to air pollutants, cigarette smoke, and workplace irritants.
- Endogenous reactive molecules in asthma, work-related asthma, and COPD target TRPA1, highlighting its role in these diseases.
Conclusions:
- TRP channels, especially TRPA1, are significant targets for oxidative/nitrative stress and environmental irritants.
- Neurogenic inflammation mediated by TRP channels is crucial in work-related inflammatory diseases.
- TRP channel antagonists represent potential novel therapeutic strategies for respiratory inflammatory conditions.
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