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Related Experiment Video

Updated: May 3, 2026

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Published on: November 18, 2022

Pycnogenol® and Centella Asiatica for asymptomatic atherosclerosis progression.

G Belcaro¹, M Dugall, M Hosoi

¹Irvine3 Circulation Sciences, Department of Biomedical Sciences, G. D'Annunzio University, Pescara, Italy - cardres@abol.it.

International Angiology : a Journal of the International Union of Angiology

|January 24, 2014

Summary

Pycnogenol and TECA supplements show promise in slowing atherosclerosis progression in low-risk individuals. This combination therapy reduced plaque buildup and oxidative stress, suggesting potential prophylactic benefits.

Related Experiment Videos

Last Updated: May 3, 2026

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Published on: November 18, 2022

Area of Science:

Cardiovascular Research
Nutritional Science
Preventive Medicine

Background:

Atherosclerosis is a growing concern, even in low-risk asymptomatic individuals with early arterial lesions.
Identifying effective interventions to slow plaque progression is crucial for long-term cardiovascular health.

Purpose of the Study:

To investigate the impact of Pycnogenol and TECA (total triterpenic fraction of Centella Asiatica) on atherosclerosis progression.
To assess the effects of these supplements on oxidative stress markers in subjects with non-stenosing plaques.

Main Methods:

An observational pilot substudy involving 1363 subjects aged 45-60 with non-stenosing carotid or femoral plaques.
Subjects were allocated to control, Pycnogenol (50 or 100 mg/day), aspirin/ticlopidine, aspirin + Pycnogenol, or Pycnogenol + TECA groups.
Plaque progression was monitored via ultrasonic arterial score over 30 months, with oxidative stress assessed at baseline and endpoint.

Main Results:

Pycnogenol at 100 mg/day, alone or in combination with TECA, significantly reduced plaque progression compared to controls and aspirin.
The Pycnogenol + TECA group exhibited the lowest rate of plaque progression (1.1%).
All Pycnogenol groups showed reduced oxidative stress, with the Pycnogenol + TECA combination demonstrating the greatest reduction.

Conclusions:

Pycnogenol and the combination of Pycnogenol + TECA appear to effectively reduce subclinical arterial lesion progression in low-risk asymptomatic individuals.
The observed benefits are linked to a significant reduction in oxidative stress.
Further large-scale randomized controlled studies are warranted to confirm the prophylactic efficacy of this combined therapy.