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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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The ureteric bud epithelium: morphogenesis and roles in metanephric kidney patterning.

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Related Experiment Video

Updated: May 3, 2026

In ovo Expression of MicroRNA in Ventral Chick Midbrain
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miRNAs in mammalian ureteric bud development.

Jing Yu1

  • 1Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA, jy4m@virginia.edu.

Pediatric Nephrology (Berlin, Germany)
|January 24, 2014
PubMed
Summary

MicroRNAs regulate kidney development by controlling ureteric bud branching and cell differentiation. Understanding these small non-coding RNAs is crucial for kidney organogenesis and preventing diseases like cystogenesis.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • The kidney's collecting duct network and ureter originate from the ureteric bud epithelium.
  • Ureteric bud branching morphogenesis is essential for generating kidney structures.
  • MicroRNAs (miRNAs) are key regulators of gene expression impacting biological processes like organogenesis.

Purpose of the Study:

  • To review the critical roles of miRNAs in ureteric bud epithelium development.
  • To explore miRNA involvement in kidney organogenesis, including branching and differentiation.
  • To summarize current knowledge on miRNA functions in collecting duct and ureter development.

Main Methods:

  • This review synthesizes existing research on miRNA functions in kidney development.

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  • It focuses on studies investigating miRNA expression and targets within the ureteric bud.
  • The review covers aspects like branching morphogenesis, cell differentiation, and cystogenesis.

    • Main Results:

    • miRNAs are crucial for regulating ureteric bud branching morphogenesis.
    • Specific miRNAs influence the terminal differentiation of collecting duct cells.
    • Dysregulation of miRNAs is implicated in the development of collecting duct cysts.

    Conclusions:

    • miRNAs play indispensable roles in normal kidney development and organogenesis.
    • Targeting miRNAs holds potential for understanding and treating kidney diseases.
    • Further research into miRNA pathways is vital for advancing regenerative medicine and nephrology.