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Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

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Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

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Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
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Mitral Valve Prolapse II: Assessment and Management01:22

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IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
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Mitral Valve Prolapse I: Introduction01:27

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IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
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"Double-ring" combined aortic and mitral valve repair.

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Corrigendum to: Management of Tricuspid Regurgitation: The Role of Transcatheter Therapies.

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Updated: May 3, 2026

Fully Endoscopic Mitral Valve Repair with Percutaneous Cannulation of Groin Vessels
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Devices for mitral valve repair.

Paolo Denti1, Francesco Maisano, Ottavio Alfieri

  • 1San Raffaele University Hospital, Via Olgettina, 60, 20100, Milan, Italy, denti.paolo@hsr.it.

Journal of Cardiovascular Translational Research
|January 24, 2014
PubMed
Summary
This summary is machine-generated.

Severe mitral regurgitation (MR) poses significant risks. Transcatheter interventions offer a less invasive alternative for high-risk patients, improving outcomes and expanding treatment options.

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Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Medical Devices

Background:

  • Severe mitral regurgitation (MR) has a poor prognosis, often leading to heart failure, arrhythmias, stroke, and mortality.
  • Many patients with severe MR are not surgical candidates due to high procedural risks, including advanced age, poor left ventricular function, and comorbidities.

Purpose of the Study:

  • To review the landscape of transcatheter mitral repair technologies as alternatives to conventional surgery for severe MR.
  • To highlight the current status and future potential of minimally invasive mitral valve interventions.

Main Methods:

  • Review of current and emerging transcatheter mitral repair technologies.
  • Categorization of devices based on anatomical and pathophysiological targets.
  • Discussion of clinical safety and efficacy of established devices like MitraClip.

Main Results:

  • MitraClip is a clinically safe and effective percutaneous option for degenerative and functional MR, mimicking surgical edge-to-edge repair.
  • Other technologies like percutaneous annuloplasty, neochordae implantation, and ventricular reshaping are in early development.
  • Combination therapies and future innovations like transcatheter valve implantation promise expanded indications and improved long-term durability.

Conclusions:

  • Transcatheter mitral interventions represent a significant advancement, offering hope for high-risk and inoperable patients with severe MR.
  • An integrated Heart Team approach is crucial for patient selection and treatment planning.
  • These evolving technologies are poised to expand treatment options and enhance patient outcomes in the near future.